University of Texas

The Aldrich Lab

The University of Texas at Austin | The School of Biological Sciences | The Section of Neurobiology | The Center for Learning and Memory


Aldrich Publications (listed by subject)


Potassium channel inactivation


Aldrich, R. W., Getting, P. A., and Thompson, S. H. Inactivation of delayed outward current in molluscan neurone somata. J. Physiol. 291: 507-530, 1979. [pdf]

Aldrich, R. W., Getting, P. A., and Thompson, S. H. Mechanism of frequency dependent broadening of molluscan neurone soma spikes. J. Physiol. 291: 531- 544, 1979. [pdf]

Aldrich, R. W. Inactivation of voltage-gated delayed potassium current in molluscan neurons: a kinetic model. Biophysical J. 36: 519-532, 1981. [pdf]

Hoshi, T., Zagotta, W.N. and Aldrich, R.W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250: 533-538, 1990. [pdf]

Zagotta, W.N., Hoshi, T. and Aldrich, R.W. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250: 568-571, 1990. [pdf]

Aldrich, R.W., Hoshi, T., and Zagotta, W.N. Differences in gating among amino-terminal variants of Shaker Potassium Channels. Cold Spring Harbor Symposium on Quantitative Biology, Vol 55, 19-27, 1990. [pdf]

Choi, K.L., Aldrich, R.W. and Yellen, G. Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels. PNAS 88: 5092-5095, 1991. [pdf]

Hoshi, T., Zagotta, W.N., and Aldrich, R.W. Two Types of Inactivation in Shaker K+ Channels: Effects of Alterations in the Carboxyl Terminal Region. Neuron 7:1-20, 1991. [pdf]

Foster, C.D., Chung, S., Zagotta, W.N., Aldrich, R.W., and Levitan, I.B. A peptide derived from the Shaker-B potassium channel produces short and long blocks of reconstituted calcium-dependent potassium channels. Neuron 9: 229-236, 1992. [pdf]

Lopez-Barneo, J., Hoshi, T., Heinemann, S.H., and Aldrich, R.W. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptions and Channels 1: 61-71, 1993. [pdf]

MacKinnon, R., Aldrich, R.W. and Lee, A.W. Functional stoichiometry of Shaker potassium channel inactivation. Science 262: 757-759, 1993. [pdf]

Murrell-Lagnado, R.D. and Aldrich, R.W. Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic pepides. Journal of General Physiology 102: 949-975, 1993. [pdf]

Murrell-Lagnado, R.D. and Aldrich, R.W. Energetics of Shaker K channel block by inactivation peptides. Journal of General Physiology 102: 977-1003, 1993. [pdf]

Drain, P., Dubin, A.E., and Aldrich, R.W. Regulation of Shaker K channel inactivation by the cyclic AMP dependent protein kinase. Neuron 12 (5): 1097-1109, 1994. [pdf]

Ogielska, E., Zagotta, W.N., Hoshi, T., Heinemann, S.H., Haab, J. and Aldrich, R.W. Cooperative Subunit Interactions in C-type Inactivation of K Channels. Biophysical Journal 69: 2449-2457, 1995. [pdf]

Ogielska, E., and Aldrich, R.W. A mutation in S6 of Shaker potassium channels decreases the K+ affinity of an ion binding site revealing ion-ion interactions in the pore. Journal of General Physiology 112:243-257, 1998. [pdf]

Ogielska, E., and Aldrich, R.W. Functional Consequences of a Decreased Potassium Affinity in a Potassium Channel Pore: Ion Interactions and C-type Inactivation. Journal of General Physiology 113:347-358, 1999. [pdf]


Sodium channel inactivation


Aldrich, R. W., Corey, D. P., and Stevens, C. F. A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306: 436-441, 1983. [pdf]

Aldrich, R. W. and Stevens, C. F. Inactivation of open and closed sodium channels determined separately. Cold Spring Harbor Symposia on Quantitative Biology, Vol. XLVIII, pp. 147-153, 1983. [pdf]

Aldrich, R. W. and Stevens, C. F. Voltage-dependent gating of single sodium channels from mammalian neuroblastoma cells. J Neurosci. 7: 418-431, 1987. [pdf]


Ion channels in Drosophila


Solc, C. K., Zagotta, W. N. and Aldrich, R. W. Single-channel and genetic analyses reveal two distinct A-type potassium channels in Drosophila. Science 236: 1094- 1098, 1987. [pdf]

Solc, C. K. and Aldrich, R. W. Voltage-gated potassium channels in larval CNS neurons of Drosophila. J. Neurosci. 8: 2556-2570, 1988. [pdf]

O'Dowd, D. and Aldrich, R. W. Voltage-clamp analysis of sodium channels in wildtype and mutant Drosophila neurons. J. Neurosci. 8; 3633-3643, 1988. [pdf]

Zagotta, W.N., Brainard, M.S., and Aldrich, R. W. Single-Channel Analysis of Four Distinct Classes of Potassium Channels in Drosophila Muscle. J. Neurosci. 8:4765- 4779, 1988. [pdf]

O'Dowd, D., Germeraad,S. and Aldrich, R.W. Alterations in the expression and gating of Drosophila sodium channels by mutations in the para gene. Neuron 2:1301- 1311, 1989. [pdf]

Zagotta, W.N., Hoshi, T. and Aldrich, R.W. Gating of single Shaker K+ channels in Drosophilia muscle and in Xenopus oocytes injected with Shaker mRNA. PNAS 86: 7243-7247, 1989. [pdf]

Zagotta, W.N., Germeraad, S., Garber, S.S., Hoshi, T., and Aldrich, R.W. Properties of ShB A-Type K+ Channels Expressed in Shaker Mutant Drosophila by Germline Transformation. Neuron 3: 773-782, 1989. [pdf]

Aldrich, R.W., Solc, C.K., Zagotta, W.N. and Brainard, M.S. Single potassium channels in Drosophila nerve and muscle. In: Keeling and Benham eds. Ion Transport, Academic Press: 73-85, 1989. [pdf]

Zagotta,W.N. and Aldrich, R.W. Voltage-dependent Gating of Shaker A-type Potassium Channels in Drosophila muscle. J.Gen. Physiol. 95: 29-60, 1990. [pdf]

Zagotta, W.N., and Aldrich R.W. Alterations in Activation Gating of Single Shaker A-type Potassium Channels by the Sh5 mutation. J. Neurosci. 10 (6): 1799-1810, 1990. [pdf]

Solc, C.K. and Aldrich, R.W. Gating of Single non-Shaker A-type Potassium Channels in Larval Drosophila Neurons. J. Gen. Physiol. 96: 135-165, 1990. [pdf]

Garber, S. S., Hoshi, T., and Aldrich, R.W. Interaction of Forskolin with Voltage-Gated K+ channels in PC12 cells. J. Neurosci. 10: 3361-3368, 1990. [pdf]

Germeraad, S., O'Dowd, D., and Aldrich, R.W. Functional assay of a putative Drosophila sodium channel gene in homozygous deficiency neurons. J. Neurogenetics 8: 1-16, 1992. [pdf]


Voltage dependent channel (Kv) activation


Hoshi, T., Zagotta, W.N. and Aldrich, R.W. Shaker Potassium Channel Gating I: Transitions near the open state. Journal of General Physiology 103: 249-278, 1994. [pdf]

Zagotta, W.N., Hoshi, T., Dittman, J. and Aldrich, R.W. Shaker Potassium Channel Gating II: Transitions in the activation pathway. Journal of General Physiology 103: 279-319, 1994. [pdf]

Zagotta, W.N., Hoshi, T., and Aldrich, R.W. Shaker Potassium Channel Gating III: Evaluation of kinetic models for activation. Journal of General Physiology 103: 321-362, 1994. [pdf]

Miller, A.G. and Aldrich, R.W. Conversion of a delayed rectifier K+ channel to a voltage-gated inward rectifier K+ channel by three amino acid substitutions. Neuron 16, 853-858, 1996. [pdf]

Smith-Maxwell, C.J., Ledwell, J.L., and Aldrich, R.W. Role of the S4 in cooperativity of voltage-dependent potassium channel activation. Journal of General Physiology 111:399-420, 1998. [pdf]

Smith-Maxwell, C.J., Ledwell, J.L., and Aldrich, R.W. Uncharged S4 residues and cooperativity in voltage-dependent potassium chanel activation. Journal of General Physiology 111:421-439, 1998. [pdf]

Zei, P.C. and Aldrich, R.W. Voltage-dependent gating of single wild-type and S4 mutant KAT1 inward rectifier potassium channels. Journal of General Physiology 112: 679-713, 1998. [pdf]

Ledwell, J.L. and Aldrich, R. W. Mutations in the S4 region isolate the final cooperative step in Shaker potassium channel activation. Journal of General Physiology 113: 389-414. 1999. [pdf]

Kanevsky, M. and Aldrich, R. W. Determinants of voltage-dependent gating and open state stability in the S5 segment ofShaker potassium channels. Journal of General
Physiology 114:215-242 1999. [pdf]

Sack J., Aldrich, R.W. and Gilly, W. A Gastropod toxin selectively slows early transitions in the Shaker K channelís activation pathway. Journal of General Physiology 123:685-696, 2004 [pdf]

Sack, J. and Aldrich, R.W. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channelís activation pathway. Journal of General Physiology 128:119-132, 2006. [pdf]


Calcium and voltage dependent channel (BK) gating


Cox, D.H., Cui, J. and Aldrich, R.W. Separation of gating properties from permeation and block in mslo large conductance Ca-activated K+ channels. Journal of General Physiology 109: 633-646, 1997. [pdf]

Cui, J., Cox, D.H. and Aldrich, R.W. Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels. Journal of General Physiology 109: 647-674, 1997. [pdf]

Cox, D.H., Cui, J. and Aldrich, R.W. Allosteric gating of a large conductance Ca-activated K+ channel. Journal of General Physiology 110: 257-281, 1997. [pdf]

Horrigan, F, Cui, J. and Aldrich, R.W. Allosteric Voltage-Gating of Potassium Channels I: mSlo Ionic Currents in the Absence of Ca2+ .Journal of General Physiology 114:277-304 1999. [pdf]

Horrigan, F, and Aldrich, R.W. Allosteric Voltage-Gating of Potassium Channels II: mSlo Channel Gating Charge Movement in the Absence of Ca2+. Journal of General Physiology 114:305-336 1999. [pdf]

Talukder, G. and Aldrich, R. W. Complex voltage-dependent behavior of single unliganded calcium sensitive potassium channels. Biophysical Journal 78: 773-784 2000. [pdf]

Cox D,H., and Aldrich R. W. Role of the ?1 Subunit in large-Conductance Ca2+-activated K+ Channel Gating Energetics: Mechanisms of Enhanced CA2+ Sensitivity Journal of General Physiology 116:411-432 2000. [pdf]

Cui, J. and Aldrich, R.W. The Allosteric Linkage between Voltage and Ca+2 Dependent Activation of BK type mslo K+ Channels. Biochemistry 39:15612-15619. 2000. [pdf]

Horrigan, F, and Aldrich, R.W., Coupling Between voltage-sensor Activation, Ca 2+ binding and Channel Opening in large Conductance (BK) Potassium Channels. Journal of General Physiology 120: 267-305. 2002. [pdf]

Piskorowski, R. and Aldrich, R.W. Calcium activation of BKCa potassium channels lacking calcium bowl and RCK domains. Nature 420:499-502. 2002. [pdf]

Li, Weiyan and Aldrich R.W. Unique inner pore properties of BK channels revealed by quaternary ammonium block. Journal of General Physiology 124:43-57, 2004. [pdf]

Piskorowski, R.A., and Aldrich, R.W. Relationship between pore occupancy and gating in BK potassium channels. Journal of General Physiology 127:557-576, 2006. [pdf]

Wilkins, C.M., and Aldrich, R.W. State independent block of BK channels by an intracellular quaternary ammonium. Journal of General Physiology 128:347-364, 2006. [pdf]

Li, Weiyan and Aldrich R.W State dependent block of BK channels by synthesized Shaker ball peptides. Journal of General Physiology 128:423-441, 2006. [pdf]


Calcium activated potasium channels in physiology


Brenner, R., Jegla, T. J., Wickenden, A., Liu, Y. and Aldrich, R .W. Cloning and Functional Characterization of Novel BK Potassium Channel Beta Subunits, hKCNMB3 and hKCNMB4. Journal of Biological Chemistry 275:6453-6461. 2000. [pdf]

Brenner, R., Perez, G.J., Bonev, A.D., Eckman, D.M., Kosec, J.C., Wiler, S.W., Patterson, A. J., Nelson, M. T., and Aldrich, R. W. Vasoregulation by the beta1 subunit of the calcium-activated potassium (BK) channel. Nature 407:870-876. 2000. [pdf]

Petkov, G.V., Bonev, A.D., Heppner, T.J., Brenner, R., Aldrich, R.W., and Nelson, M.T., Beta1 -Subunit of the Ca 2+ activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle. Journal of Physiology 537: 443-452. 2001. [pdf]

Meredith A. L., K. S. Thorneloe, M. E. Werner, M. T. Nelson, and R. W. Aldrich (2004) Overactive bladder and incontinence in the absence of the BK Ca2+ - activated K+ channel. Journal of Biological Chemistry 279:36746-36752 (published on line June 2004). [pdf]

Pyott, S.J., Glowatski, E., Trimmer, J.S. and Aldrich Extrasynaptic Localization of Inactivating Calcium-Activated Channels in Mouse Inner Hair Cells. Journal of Neuroscience. 24:9469-9474, 2004. [pdf]

Thorneloe, K.S., Meredith, A.L., Aldrich, R.W. and Nelson, M.T. (2005) Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. American Journal of Physiology, Renal Physiology 289:604-610 published on line April 12. 2005). [pdf]

Werner, M.E., Zvara, P., Meredith, A.L., Aldrich, R.W., and Nelson M.T. (2005) Erectile dysfunction in mice lacking the large conductance calcium-activated potassium (BK) channel Journal of Physiology 567:545-556 (published on line July 14. 2005). [pdf]

Brenner, R., Chen, Q.H., Vilaythong, A., Toney, G.N., Noebels, J.L., and Aldrich, R.W. BK channel ?4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures. Nature Neuroscience 8:1752-1759, 2005. [pdf]

Wei, A. D., Gutman, G. A., Aldrich, R., Chandy, K. G., Grissmer, S. and Wulff, H. (2005) International Union of Pharmacology. LII. Nomenclature and Molecular Relationships of Calcium-Activated Potassium Channels. Pharmacol Rev 57:463-472. [pdf]

Misonou, H., Menegola, M., Buchwalder, L., Park, E.W., Meredith, A., Rhodes, K.J., Aldrich, R.W., and Trimmer, J.S. Immunolocalization of the Ca2+-activated K Channel Slo1 in Axons and Nerve Terminals of Mammalian Brain and Cultured Neurons. Journal of Comparative Neurology 496:289-302, 2006. [pdf]

Meredith, A.L., Wiler, S.W, Miller, B.H., Takahashi, J.S., Fodor, A.A. Ruby N. F., and Aldrich, R.W. (2006) BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output Nature Neuroscience 9:1042-1049. [pdf]

Werner, M. E., Knorn, A., Meredith A. L., Aldrich, R. W. and Nelson, M. T. (2006) Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: Modulation by BK channels. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 292:616-624 (published online Sept. 24 2006). [pdf]

Filosa, J. A., Bonev, A. D., Straub, S. V., Meredith, A. L,. Aldrich, R. W. and Nelson, M. T. (2006) Local potassium signaling couples neuronal activity to vasodilation in the brain. Nature Neuroscience 9:1397-1403. [pdf]

Pyott, S.J., Meredith, A.L., Fodor, A.F., Vazquez, A.E., Yamoah, E.N. and Aldrich, R. W. (2007) Cochlear Function in Mice Lacking the BK channel ?, ?1, or ?4 subunits. Journal of Biological Chemistry 282:3313-3324. (Published online November 29, 2006). [pdf]


Informatics approaches to protein structure and function


Decker, J.P, Fodor, A., Aldrich, R.W. and Yellen, G. (2004) A perturbation-based method for calculating explicit likelihood of evolutionary covariance in multiple sequence alignments. Bioinformatics 20: 1565-1572. (published online February 12, 2004). [pdf]

Fodor A.A., and Aldrich R.W. (2004) Influence of Conservation on Calculations of Amino Acid Covariance in Multiple sequence Alignments. Proteins: Structure, Function and Bioinformatics 56:211-221. 2004 (published online May 14, 2004). [pdf]

Fodor A.A., and Aldrich R.W. (2004) On evolutionary conservation of thermodynamic coupling in proteins. Journal of Biological Chemistry 279:19046-19050 (Published online on March 15, 2004). [pdf]

Fodor, A. and Aldrich, R.W. (2006) Statistical limits to the identification of ion channel domains by sequence similarity. Journal of General Physiology 127:755-766. [pdf]


Potassium channel diversity,and regulation in pheochromocytoma cells


Hoshi, T. and Aldrich, R. W. Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells. J. Gen. Physiol. 91: 73-106, 1988. [pdf]

Hoshi, T. and Aldrich, R. W. Gating kinetics of four classes of voltage-dependent K+ channels in pheochromocytoma cells. J. Gen. Physiol. 91: 107-131, 1988. [pdf]

Hoshi, T., Garber, S. S. and Aldrich, R.W. Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation. Science 240: 1652-1655, 1988. [pdf]

Garber, S. S., Hoshi, T., Aldrich, R. W. Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone. J. Neurosci. 9: 3976-3987, 1989. [pdf]


Calcium Channels


Zhang, J-F., Ellinor, P.T., Aldrich, R.W. and Tsien, R.W. Molecular determinants of voltage-dependent inactivation in calcium channels. Nature 372: 97-100, 1994. [pdf]

Zhang, J-F., Ellinor, P.T., Aldrich, R.W. and Tsien, R.W. Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins. Neuron 17, 991-1003, 1996. [pdf]

Stocker, J.W., Nadasdi, L., Aldrich, R.W. and Tsien, R.W. Preferential interaction of omega-conotoxins with inactivated N-type Ca2+ channels. J. Neuroscience, 17(9): 3002-3013, 1997. [pdf]


Cyclic Nucleotide activated channels


Middendorf, T.R., Aldrich, R.W. and Baylor D.A., Modification of Cyclic Nucleotide-Gated Ion Channels by Ultraviolet Light. Journal of General Physiology 116:227-252 2000. [pdf]

Middendorf, T.R., and Aldrich, R.W. Effects of Ultraviolet Modification on the Gating Energetics of Cyclic Nucleotide-Gated Channels. Journal of General Physiology 116:253-282, 2000. [pdf]


Bradykinin receptor


McEachern, A.E., Shelton, E.R., Bhakta, S., Obernolte, R., Bach, C., Zuppan, P., Fujisaki, J., Aldrich, R.W. and Jarnagin, K. Expression cloning of a rat B2 bradykinin receptor. PNAS 88: 7724-7728, 1991. [pdf]


Calcium indicators


Hollingsworth, S., Aldrich, R. W. and Baylor, S. M. In vitro calibration of the equilibrium reactions of the metallochromic indicator dye antipyrylazo III with calcium. Biophys. J. 5l: 383-393, 1987. [pdf]


Reviews


Thompson, S. H., and Aldrich, R. W. Membrane potassium channels. In: C. W. Cotman, G. Poste, and G. L. Nicolson (eds.), The Cell Surface and Neuronal Function, Elsevier/North-Holland, pp. 49-85, 1980. [pdf]

Aldrich, R. W., and Yellen, G. Analysis of nonstationary channel kinetics. In: B. Sakmann and E. Neher (eds.), Single Channel Recording, Plenum Press, pp. 281-299, 1983. [pdf]

Aldrich, R. W., Dionne, V. E., Hawrot, E., and Stevens, C. F. Ion transport through ligand gated channels. In: T. E. Andreoli, J. F. Hoffman, D. D. Fanestil, and S. G. Schultz (eds.), Physiology of Membrane Disorders, Plenum Press, pp. 491-516, 1986. [pdf]

Aldrich, R. W. Voltage dependent gating of sodium channels: towards an integrated approach, Trends in Neuroscience 9: 82-86, 1986. [pdf]