Potassium channel inactivation
Aldrich, R. W., Getting, P. A., and Thompson, S. H. Inactivation of delayed outward current in molluscan neurone somata. J. Physiol. 291: 507-530, 1979. [pdf]
Aldrich, R. W., Getting, P. A., and Thompson, S. H. Mechanism of frequency dependent broadening of molluscan neurone soma spikes. J. Physiol. 291: 531-
544, 1979. [pdf]
Aldrich, R. W. Inactivation of voltage-gated delayed potassium current in molluscan neurons: a kinetic model. Biophysical J. 36: 519-532, 1981. [pdf]
Hoshi, T., Zagotta, W.N. and Aldrich, R.W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250: 533-538, 1990. [pdf]
Zagotta, W.N., Hoshi, T. and Aldrich, R.W. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250:
568-571, 1990. [pdf]
Aldrich, R.W., Hoshi, T., and Zagotta, W.N. Differences in gating among amino-terminal variants of Shaker Potassium Channels. Cold Spring Harbor Symposium
on Quantitative Biology, Vol 55, 19-27, 1990. [pdf]
Choi, K.L., Aldrich, R.W. and Yellen, G. Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels. PNAS 88:
5092-5095, 1991. [pdf]
Hoshi, T., Zagotta, W.N., and Aldrich, R.W. Two Types of Inactivation in Shaker K+ Channels: Effects of Alterations in the Carboxyl Terminal Region. Neuron
7:1-20, 1991. [pdf]
Foster, C.D., Chung, S., Zagotta, W.N., Aldrich, R.W., and Levitan, I.B. A peptide derived from the Shaker-B potassium channel produces short and long blocks
of reconstituted calcium-dependent potassium channels. Neuron 9: 229-236, 1992. [pdf]
Lopez-Barneo, J., Hoshi, T., Heinemann, S.H., and Aldrich, R.W. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker
potassium channels. Receptions and Channels 1: 61-71, 1993. [pdf]
MacKinnon, R., Aldrich, R.W. and Lee, A.W. Functional stoichiometry of Shaker potassium channel inactivation. Science 262: 757-759, 1993. [pdf]
Murrell-Lagnado, R.D. and Aldrich, R.W. Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic pepides.
Journal of General Physiology 102: 949-975, 1993. [pdf]
Murrell-Lagnado, R.D. and Aldrich, R.W. Energetics of Shaker K channel block by inactivation peptides. Journal of General Physiology 102: 977-1003, 1993. [pdf]
Drain, P., Dubin, A.E., and Aldrich, R.W. Regulation of Shaker K channel inactivation by the cyclic AMP dependent protein kinase. Neuron 12 (5): 1097-1109,
1994. [pdf]
Ogielska, E., Zagotta, W.N., Hoshi, T., Heinemann, S.H., Haab, J. and Aldrich, R.W. Cooperative Subunit Interactions in C-type Inactivation of K Channels.
Biophysical Journal 69: 2449-2457, 1995. [pdf]
Ogielska, E., and Aldrich, R.W. A mutation in S6 of Shaker potassium channels decreases the K+ affinity of an ion binding site revealing ion-ion interactions
in the pore. Journal of General Physiology 112:243-257, 1998. [pdf]
Ogielska, E., and Aldrich, R.W. Functional Consequences of a Decreased Potassium Affinity in a Potassium Channel Pore: Ion Interactions and C-type Inactivation.
Journal of General Physiology 113:347-358, 1999. [pdf]
Sodium channel inactivation
Aldrich, R. W., Corey, D. P., and Stevens, C. F. A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306: 436-441,
1983. [pdf]
Aldrich, R. W. and Stevens, C. F. Inactivation of open and closed sodium channels determined separately. Cold Spring Harbor Symposia on Quantitative Biology,
Vol. XLVIII, pp. 147-153, 1983. [pdf]
Aldrich, R. W. and Stevens, C. F. Voltage-dependent gating of single sodium channels from mammalian neuroblastoma cells. J Neurosci. 7: 418-431, 1987. [pdf]
Ion channels in Drosophila
Solc, C. K., Zagotta, W. N. and Aldrich, R. W. Single-channel and genetic analyses reveal two distinct A-type potassium channels in Drosophila. Science 236: 1094-
1098, 1987. [pdf]
Solc, C. K. and Aldrich, R. W. Voltage-gated potassium channels in larval CNS neurons of Drosophila.
J. Neurosci. 8: 2556-2570, 1988. [pdf]
O'Dowd, D. and Aldrich, R. W. Voltage-clamp analysis of sodium channels in wildtype and mutant Drosophila neurons. J. Neurosci. 8; 3633-3643, 1988. [pdf]
Zagotta, W.N., Brainard, M.S., and Aldrich, R. W. Single-Channel Analysis of Four Distinct Classes of Potassium Channels in Drosophila Muscle. J. Neurosci. 8:4765-
4779, 1988. [pdf]
O'Dowd, D., Germeraad,S. and Aldrich, R.W. Alterations in the expression and gating of Drosophila sodium channels by mutations in the para gene. Neuron 2:1301-
1311, 1989. [pdf]
Zagotta, W.N., Hoshi, T. and Aldrich, R.W. Gating of single Shaker K+ channels in Drosophilia muscle and in Xenopus oocytes injected with Shaker mRNA. PNAS 86:
7243-7247, 1989. [pdf]
Zagotta, W.N., Germeraad, S., Garber, S.S., Hoshi, T., and Aldrich, R.W. Properties of ShB A-Type K+ Channels Expressed in Shaker Mutant Drosophila by Germline
Transformation. Neuron 3: 773-782, 1989. [pdf]
Aldrich, R.W., Solc, C.K., Zagotta, W.N. and Brainard, M.S. Single potassium channels in Drosophila nerve and muscle. In: Keeling and Benham eds. Ion Transport,
Academic Press: 73-85, 1989. [pdf]
Zagotta,W.N. and Aldrich, R.W. Voltage-dependent Gating of Shaker A-type Potassium Channels in Drosophila muscle. J.Gen. Physiol. 95: 29-60, 1990. [pdf]
Zagotta, W.N., and Aldrich R.W. Alterations in Activation Gating of Single Shaker A-type Potassium Channels by the Sh5 mutation. J. Neurosci. 10 (6): 1799-1810,
1990. [pdf]
Solc, C.K. and Aldrich, R.W. Gating of Single non-Shaker A-type Potassium Channels in Larval Drosophila Neurons. J. Gen. Physiol. 96: 135-165, 1990. [pdf]
Garber, S. S., Hoshi, T., and Aldrich, R.W. Interaction of Forskolin with Voltage-Gated K+ channels in PC12 cells. J. Neurosci. 10: 3361-3368, 1990. [pdf]
Germeraad, S., O'Dowd, D., and Aldrich, R.W. Functional assay of a putative Drosophila sodium channel gene in homozygous deficiency neurons. J. Neurogenetics 8:
1-16, 1992. [pdf]
Voltage dependent channel (Kv) activation
Hoshi, T., Zagotta, W.N. and Aldrich, R.W. Shaker Potassium Channel Gating I: Transitions near the open state. Journal of General Physiology 103: 249-278, 1994. [pdf]
Zagotta, W.N., Hoshi, T., Dittman, J. and Aldrich, R.W. Shaker Potassium Channel Gating II: Transitions in the activation pathway. Journal of General Physiology
103: 279-319, 1994. [pdf]
Zagotta, W.N., Hoshi, T., and Aldrich, R.W. Shaker Potassium Channel Gating III: Evaluation of kinetic models for activation. Journal of General Physiology 103:
321-362, 1994. [pdf]
Miller, A.G. and Aldrich, R.W. Conversion of a delayed rectifier K+ channel to a voltage-gated inward rectifier K+ channel by three amino acid substitutions. Neuron
16, 853-858, 1996. [pdf]
Smith-Maxwell, C.J., Ledwell, J.L., and Aldrich, R.W. Role of the S4 in cooperativity of voltage-dependent potassium channel activation. Journal of General Physiology
111:399-420, 1998. [pdf]
Smith-Maxwell, C.J., Ledwell, J.L., and Aldrich, R.W. Uncharged S4 residues and cooperativity in voltage-dependent potassium chanel activation. Journal of General
Physiology 111:421-439, 1998. [pdf]
Zei, P.C. and Aldrich, R.W. Voltage-dependent gating of single wild-type and S4 mutant KAT1 inward rectifier potassium channels. Journal of General Physiology 112:
679-713, 1998. [pdf]
Ledwell, J.L. and Aldrich, R. W. Mutations in the S4 region isolate the final cooperative step in Shaker potassium channel activation. Journal of General Physiology
113: 389-414. 1999. [pdf]
Kanevsky, M. and Aldrich, R. W. Determinants of voltage-dependent gating and open state stability in the S5 segment ofShaker potassium channels. Journal of General
Physiology 114:215-242 1999. [pdf]
Sack J., Aldrich, R.W. and Gilly, W. A Gastropod toxin selectively slows early transitions in the Shaker K channel’s activation pathway. Journal of General
Physiology 123:685-696, 2004 [pdf]
Sack, J. and Aldrich, R.W. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel’s activation pathway.
Journal of General Physiology 128:119-132, 2006. [pdf]
Calcium and voltage dependent channel (BK) gating
Cox, D.H., Cui, J. and Aldrich, R.W. Separation of gating properties from permeation and block in mslo large conductance Ca-activated K+ channels. Journal of General
Physiology 109: 633-646, 1997. [pdf]
Cui, J., Cox, D.H. and Aldrich, R.W. Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels. Journal of General Physiology
109: 647-674, 1997. [pdf]
Cox, D.H., Cui, J. and Aldrich, R.W. Allosteric gating of a large conductance Ca-activated K+ channel. Journal of General Physiology 110: 257-281, 1997. [pdf]
Horrigan, F, Cui, J. and Aldrich, R.W. Allosteric Voltage-Gating of Potassium Channels I: mSlo Ionic Currents in the Absence of Ca2+ .Journal of General Physiology
114:277-304 1999. [pdf]
Horrigan, F, and Aldrich, R.W. Allosteric Voltage-Gating of Potassium Channels II: mSlo Channel Gating Charge Movement in the Absence of Ca2+. Journal of General Physiology
114:305-336 1999. [pdf]
Talukder, G. and Aldrich, R. W. Complex voltage-dependent behavior of single unliganded calcium sensitive potassium channels. Biophysical Journal 78: 773-784 2000. [pdf]
Cox D,H., and Aldrich R. W. Role of the ?1 Subunit in large-Conductance Ca2+-activated K+ Channel Gating Energetics: Mechanisms of Enhanced CA2+ Sensitivity Journal of General
Physiology 116:411-432 2000. [pdf]
Cui, J. and Aldrich, R.W. The Allosteric Linkage between Voltage and Ca+2 Dependent Activation of BK type mslo K+ Channels. Biochemistry 39:15612-15619. 2000. [pdf]
Horrigan, F, and Aldrich, R.W., Coupling Between voltage-sensor Activation, Ca 2+ binding and Channel Opening in large Conductance (BK) Potassium Channels. Journal of General
Physiology 120: 267-305. 2002. [pdf]
Piskorowski, R. and Aldrich, R.W. Calcium activation of BKCa potassium channels lacking calcium bowl and RCK domains. Nature 420:499-502. 2002. [pdf]
Li, Weiyan and Aldrich R.W. Unique inner pore properties of BK channels revealed by quaternary ammonium block. Journal of General Physiology 124:43-57, 2004. [pdf]
Piskorowski, R.A., and Aldrich, R.W. Relationship between pore occupancy and gating in BK potassium channels. Journal of General Physiology 127:557-576, 2006. [pdf]
Wilkins, C.M., and Aldrich, R.W. State independent block of BK channels by an intracellular quaternary ammonium. Journal of General Physiology 128:347-364, 2006. [pdf]
Li, Weiyan and Aldrich R.W State dependent block of BK channels by synthesized Shaker ball peptides. Journal of General Physiology 128:423-441, 2006. [pdf]
Calcium activated potasium channels in physiology
Brenner, R., Jegla, T. J., Wickenden, A., Liu, Y. and Aldrich, R .W. Cloning and Functional Characterization of Novel BK Potassium Channel Beta Subunits, hKCNMB3 and hKCNMB4.
Journal of Biological Chemistry 275:6453-6461. 2000. [pdf]
Brenner, R., Perez, G.J., Bonev, A.D., Eckman, D.M., Kosec, J.C., Wiler, S.W., Patterson, A. J., Nelson, M. T., and Aldrich, R. W. Vasoregulation by the beta1 subunit of
the calcium-activated potassium (BK) channel. Nature 407:870-876. 2000. [pdf]
Petkov, G.V., Bonev, A.D., Heppner, T.J., Brenner, R., Aldrich, R.W., and Nelson, M.T., Beta1 -Subunit of the Ca 2+ activated K+ channel regulates contractile activity of mouse
urinary bladder smooth muscle. Journal of Physiology 537: 443-452. 2001. [pdf]
Meredith A. L., K. S. Thorneloe, M. E. Werner, M. T. Nelson, and R. W. Aldrich (2004) Overactive bladder and incontinence in the absence of the BK Ca2+ - activated K+ channel.
Journal of Biological Chemistry 279:36746-36752 (published on line June 2004). [pdf]
Pyott, S.J., Glowatski, E., Trimmer, J.S. and Aldrich Extrasynaptic Localization of Inactivating Calcium-Activated Channels in Mouse Inner Hair Cells. Journal of
Neuroscience. 24:9469-9474, 2004. [pdf]
Thorneloe, K.S., Meredith, A.L., Aldrich, R.W. and Nelson, M.T. (2005) Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel
deletion model of overactive bladder. American Journal of Physiology, Renal Physiology 289:604-610 published on line April 12. 2005). [pdf]
Werner, M.E., Zvara, P., Meredith, A.L., Aldrich, R.W., and Nelson M.T. (2005) Erectile dysfunction in mice lacking the large conductance calcium-activated potassium (BK) channel
Journal of Physiology 567:545-556 (published on line July 14. 2005). [pdf]
Brenner, R., Chen, Q.H., Vilaythong, A., Toney, G.N., Noebels, J.L., and Aldrich, R.W. BK channel ?4 subunit reduces dentate gyrus excitability and protects against
temporal lobe seizures. Nature Neuroscience 8:1752-1759, 2005. [pdf]
Wei, A. D., Gutman, G. A., Aldrich, R., Chandy, K. G., Grissmer, S. and Wulff, H. (2005) International Union of Pharmacology. LII. Nomenclature and Molecular Relationships of
Calcium-Activated Potassium Channels. Pharmacol Rev 57:463-472. [pdf]
Misonou, H., Menegola, M., Buchwalder, L., Park, E.W., Meredith, A., Rhodes, K.J., Aldrich, R.W., and Trimmer, J.S.
Immunolocalization of the Ca2+-activated K Channel Slo1 in Axons and Nerve Terminals of Mammalian Brain and Cultured Neurons. Journal of Comparative Neurology 496:289-302, 2006. [pdf]
Meredith, A.L., Wiler, S.W, Miller, B.H., Takahashi, J.S., Fodor, A.A. Ruby N. F., and Aldrich, R.W. (2006) BK calcium-activated potassium channels regulate circadian behavioral
rhythms and pacemaker output Nature Neuroscience 9:1042-1049. [pdf]
Werner, M. E., Knorn, A., Meredith A. L., Aldrich, R. W. and Nelson, M. T. (2006) Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder
smooth muscle: Modulation by BK channels. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 292:616-624 (published online Sept. 24 2006). [pdf]
Filosa, J. A., Bonev, A. D., Straub, S. V., Meredith, A. L,. Aldrich, R. W. and Nelson, M. T. (2006) Local potassium signaling couples neuronal activity to vasodilation in the brain.
Nature Neuroscience 9:1397-1403. [pdf]
Pyott, S.J., Meredith, A.L., Fodor, A.F., Vazquez, A.E., Yamoah, E.N. and Aldrich, R. W. (2007) Cochlear Function in Mice Lacking the BK channel ?, ?1, or ?4 subunits. Journal of
Biological Chemistry 282:3313-3324. (Published online November 29, 2006). [pdf]
Informatics approaches to protein structure and function
Decker, J.P, Fodor, A., Aldrich, R.W. and Yellen, G. (2004) A perturbation-based method for calculating explicit likelihood of evolutionary covariance in multiple sequence alignments.
Bioinformatics 20: 1565-1572. (published online February 12, 2004). [pdf]
Fodor A.A., and Aldrich R.W. (2004) Influence of Conservation on Calculations of Amino Acid Covariance in Multiple sequence Alignments. Proteins: Structure, Function and
Bioinformatics 56:211-221. 2004 (published online May 14, 2004). [pdf]
Fodor A.A., and Aldrich R.W. (2004) On evolutionary conservation of thermodynamic coupling in proteins. Journal of Biological Chemistry 279:19046-19050 (Published online on March 15, 2004). [pdf]
Fodor, A. and Aldrich, R.W. (2006) Statistical limits to the identification of ion channel domains by sequence similarity. Journal of General Physiology 127:755-766. [pdf]
Potassium channel diversity,and regulation in pheochromocytoma cells
Hoshi, T. and Aldrich, R. W. Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells. J. Gen. Physiol. 91: 73-106, 1988. [pdf]
Hoshi, T. and Aldrich, R. W. Gating kinetics of four classes of voltage-dependent K+ channels in pheochromocytoma cells. J. Gen. Physiol. 91: 107-131, 1988. [pdf]
Hoshi, T., Garber, S. S. and Aldrich, R.W. Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation. Science 240: 1652-1655, 1988. [pdf]
Garber, S. S., Hoshi, T., Aldrich, R. W. Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone. J. Neurosci. 9: 3976-3987, 1989. [pdf]
Calcium Channels
Zhang, J-F., Ellinor, P.T., Aldrich, R.W. and Tsien, R.W. Molecular determinants of voltage-dependent inactivation in calcium channels. Nature 372: 97-100, 1994. [pdf]
Zhang, J-F., Ellinor, P.T., Aldrich, R.W. and Tsien, R.W. Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins. Neuron 17,
991-1003, 1996. [pdf]
Stocker, J.W., Nadasdi, L., Aldrich, R.W. and Tsien, R.W. Preferential interaction of omega-conotoxins with inactivated N-type Ca2+ channels. J. Neuroscience, 17(9): 3002-3013,
1997. [pdf]
Cyclic Nucleotide activated channels
Middendorf, T.R., Aldrich, R.W. and Baylor D.A., Modification of Cyclic Nucleotide-Gated Ion Channels by Ultraviolet Light. Journal of General Physiology 116:227-252 2000. [pdf]
Middendorf, T.R., and Aldrich, R.W. Effects of Ultraviolet Modification on the Gating Energetics of Cyclic Nucleotide-Gated Channels. Journal of General Physiology 116:253-282,
2000. [pdf]
Bradykinin receptor
McEachern, A.E., Shelton, E.R., Bhakta, S., Obernolte, R., Bach, C., Zuppan, P., Fujisaki, J., Aldrich, R.W. and Jarnagin, K. Expression cloning of a rat B2 bradykinin receptor.
PNAS 88: 7724-7728, 1991. [pdf]
Calcium indicators
Hollingsworth, S., Aldrich, R. W. and Baylor, S. M. In vitro calibration of the equilibrium reactions of the metallochromic indicator dye antipyrylazo III with calcium. Biophys. J.
5l: 383-393, 1987. [pdf]
Reviews
Thompson, S. H., and Aldrich, R. W. Membrane potassium channels. In: C. W. Cotman, G. Poste, and G. L. Nicolson (eds.), The Cell Surface and Neuronal Function, Elsevier/North-Holland,
pp. 49-85, 1980. [pdf]
Aldrich, R. W., and Yellen, G. Analysis of nonstationary channel kinetics. In: B. Sakmann and E. Neher (eds.), Single Channel Recording, Plenum Press, pp. 281-299, 1983. [pdf]
Aldrich, R. W., Dionne, V. E., Hawrot, E., and Stevens, C. F. Ion transport through ligand gated channels. In: T. E. Andreoli, J. F. Hoffman, D. D. Fanestil, and S. G. Schultz (eds.), Physiology of Membrane Disorders, Plenum Press, pp. 491-516, 1986. [pdf]
Aldrich, R. W. Voltage dependent gating of sodium channels: towards an integrated approach, Trends in Neuroscience 9: 82-86, 1986. [pdf]