Aldrich Lab publishes back-to-back papers in Journal of General Physiology

Dr. Tom Middendorf and Rick Aldrich recently published companion papers in the Journal of General Physiology entitled “Structural identifiability of equilibrium ligand-binding parameters”, and “The structure of binding curves and practical identifiability of equilibrium ligand-binding parameters.” The former paper presents  a method to determine the accuracy of ligand-protein binding parameters estimated from models of agonist binding.  The companion paper presents an approach to determine whether binding parameters can be accurately estimated from experimental, or noisy, data.

Middendorf TR and Aldrich RW. 2017. Structural identifiability of equilibrium ligand-binding parameters. Journal of General Physiology. 149(1):105-119

Middendorf TR and Aldrich RW. 2017. The structure of binding curves and practical identifiability of equilibrium ligand-binding parameters. Journal of General Physiology. 149(1): 121-147

 

 

 

 

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