The Aldrich lab recently published 2 papers in The Journal of General Physiology and one in the Proceedings of the National Academy of Sciences.
Brent Halling is first author on a paper published in the Journal of General Physiology entitled “Calcium-dependent stoichiometries of the KCa2.2 (SK) intracellular domain/calmodulin complex in solution”. SK calcium-activated potassium channels are involved in many physiological processes and they bind calcium by way of the calcium binding protein calmodulin. This paper researches the mechanism of SK channel activation by investigating how Ca2+ regulates Calmodulin binding to its target on SK .
Halling DB, Kenrick AS, Riggs AF and Aldrich RW. (2014). Journal of General Physiology, 143(2):231-252.
Xixi Chen is first author on a paper published in PNAS entitled “BK channel opening involves side-chain reorientation of multiple deep-pore residues“. BK calcium-activated potassium channels are important regulators of electrical and calcium signaling in many types of tissue. BK channel activation involves complex conformational changes. This research investigated the molecular details of such conformational changes with scanning mutagenesis and electrophysiological measurements.
Chen X, Yan J and Aldrich RW. (2014). PNAS 111(1):E79-E88
Keegan Hines and Tom Middendorf are co-authors on a paper in press in the Journal of General Physiology entitled “Determination of Parameter Identifiability in Nonlinear Biophysical Models: A Bayesian Approach“. This research takes a statistical approach, based on Baysean inference, to determine the degree of uncertainty ion parameter estimates. Journal of General Physiology, In Press