The Harris lab recently published research articles the Journal of Comparative Neurology and the Journal of Neurophysiology.
The Journal of Comparative Neurology paper is entitled “Dynamics of Nascent and Active Zone Ultrastructure as Synapses Enlarge During Long-Term Potentiation in Mature Hippocampus”. This work investigates the dynamics of nascent and active zones at dendritic spine synapses. Nascent zones and active zones share a postsynaptic density, but presynaptic vesicles congregate only at active zones. This research provides new evidence that nascent zones are dynamic substrates for constitutive synaptogenesis and LTP-induced synapse enlargement in mature hippocampus.
ME Bell, JN Bourne, MA Chirillo, JM Mendenhall, M Kuwajima and KM Harris. (2014). Dynamics of nascent and active zone ultrastructure as synapses enlarge during long-term potentiation in mature hippocampus. Published online July 10.
The paper appearing in the Journal of Neurophysiology is entitled “Augmenting saturated LTP by broadly spaced episodes of theta-burst stimulation in hippocampal area CA1 of adult rats and mice”. This work investigates the affect that strength and pattern of stimulation, as well as the age of the animal, has on the induction of long-term potentiation (LTP), a widely accepted model for studying the cellular and molecular mechanisms of learning and memory.
G Cao and KM Harris. (2014). Augmenting saturated LTP by broadly spaced episodes of theta-burst stimulation in hippocampal area CA1 of adult rats and mice. Epub ahead of print, July 23.