Adult Hippocampal Neurogenesis

Drew MR, Huckleberry KA (2017) Modulation of Aversive Memory by Adult Hippocampal Neurogenesis. Neurotherapeutics 435:406–416.

Seo D-O, Carillo MA, Chih-Hsiung Lim S, Tanaka KF, Drew MR. Adult Hippocampal Neurogenesis Modulates Fear Learning through Associative and Nonassociative Mechanisms. Journal of Neuroscience. 2015;35(32):11330-11345.

Huckleberry KA, Kane GA, Mathis RJ, Cook SG, Clutton JE, Drew MR. Behavioral experience induces zif268 expression in mature granule cells but suppresses its expression in immature granule cells. Front Syst Neurosci. 2015;9:1-9.

Swan, A.A., Clutton, J.E., Chary, P.K., Cook, S.G., Liu, G.G., & Drew, M.R. (2014) Characterization of the role of adult neurogenesis in touch-screen discrimination learning. Hippocampus.

Denny, C.A., Burghardt N.S., Schachter D.M., Hen R., Drew M.R. (2012) 4- to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning. Hippocampus. [pdf]

Drew, M.R., Denny, C.A., & Hen, R. (2010).  Arrest of adult hippocampal neurogenesis impairs single- but not multiple-trial contextual fear conditioning. Behavioral Neuroscience, 124, 446-54. [pdf]

David, D.J., Samuels, B.A., Rainer, Q., Wang, J.W., Marsteller, D., Mendez, I., Drew, M.R., Craig, D.A., Giard, B.P., Guilloux, J.P., Artymyshyn, R.P., Gardier, A.M., Gerald, C., Antonijevic, I.A., Hen, R. (2009). Behavioral Effects Of Fluoxetine In An Animal Model Of Anxiety/Depression Are Mediated By Both Neurogenesis-Dependent And Independent Mechanisms.  Neuron, 62, 479-93.  [pdf]

Pollak D.D., Monje, F.J., Zuckerman L., Denny, C.A., Drew, M.R., & Kandel, E.R. (2008). Conditioned Inhibtion of Fear Acts as a Behavioral Antidepressant.  Neuron, 60, 149-61.  [pdf]

Drew, M.R. & Hen, R.H. (2007). Adult hippocampal neurogenesis as a target of antidepressant treatments. CNS & Neurological Disorders – Drug Targets, 6, 205-18. [pdf]

Sahay, A., Drew, M.R, & Hen, R. (2007). Dentate Gyrus Neurogenesis and Depression. Progress in Brain Research, 163, 697-722. [pdf]

Saxe, M.D., Battaglia, F., Wang, J.W., Malleret, G., David, D.J., Monckton, J.E., Garcia, D.R., Sofroniew, M.V., Kandel, E.R., Santarelli, L., Hen, R., & Drew, M.R. (2006). Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proceedings of the National Academy of Sciences,103,17501-506.   [pdf]

*Meshi, D.B., *Drew, M.R., Moore, H., Malapani, C., Hen., R.. (2006). Hippocampal neurogenesis is not required for the effect of environmental enrichment on spatial learning and anxiety-like behavior. Nature Neuroscience, 9, 729-31. [pdf]


Bernier BE, Lacagnina AF, Ayoub A, Shue F, Zemelman BV, Krasne FB, Drew MR (2017) Dentate gyrus contributes to retrieval as well as encoding: Evidence from context fear conditioning, recall, and extinction. Journal of Neuroscience:3029–16–13.

Bernier BE, Lacagnina AF, Drew MR. Potent attenuation of context fear by extinction training contiguous with acquisition. Learning & Memory. 2014;22(1):31-38.

Time and Associative Learning

Drew MR, Walsh C, Balsam PD (2017) Rescaling of temporal expectations during extinction. Journal of Experimental Psychology: Animal Learning and Cognition 43:1–14.

Balsam, P.D., Drew, M.R., Gallistel, C.R. (2010). Time and Associative Learning.  Comparative Cognition & Behavior Reviews, 5, 1-22. [pdf]

Drew, M.R., Zupan, B., Cooke, A., Couvillon, P.A., & Balsam, P.D. (2005).  Temporal control of conditioned responding in goldfish.  Journal of Experimental Psychology: Animal Behavior Processes, 31, 31-39. [pdf]

Drew, M.R., Yang, C., & Balsam, P.D. (2004). Temporal Specificity of Extinction in Autoshaping. Journal of Experimental Psychology: Animal Behavior Processes 30, 163-176. [pdf]

Balsam, P.D., Drew, M.R., & Yang, C. (2002). Timing at the start of associative learning.  Learning & Motivation, 33, 141-155. [pdf]

Dopamine and Timing

Drew M.R., Simpson E.H., Kellendonk C., Herzberg W.G., Lipatova O., Fairhurst S., Kandel E.R., Malapani C., Balsam P.D. (2007). Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. Journal of Neuroscience, 27, 7731-9. [pdf]

Drew M.R., Fairhurst S., Malapani C., Horvitz J.C., Balsam P.D. (2003). Effects of dopamine antagonists on the timing of two intervals. Pharmacology, Biochemistry, and Behavior, 75, 9-15. [pdf]

Ward, R.D., Kellendonk, C., Simpson, E.H., Lipatova, O., Drew, M.R., Fairhurst, S., Kandel, E.R., Balsam, P.D. (2009). Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits. Behavioral Neuroscience, 123, 720-730. [pdf]

Ohyama, T., Horvitz, J.C., Drew, M.R., Gibbon, J., Malapani, C. & Balsam, P.D (2001).  Conditioned and unconditioned behavior/cognitive effects of a dopamine antagonist. Behavioral Neuroscience, 114,1251 1255. [pdf]