Publications

Khilkevich, A., Halverson, H. E., Canton-Josh, J.E. & Mauk, M. D.  Links Between Single Trial Changes and Learning Rate in Eyelid Conditioning. Cerebellum (In Press) [pdf

Halverson, H. E., Khilkevich, A. &  Mauk, M. D. Relating Purkinje cell activity to the timing and amplitude of conditioned eyelid responses.  Journal of Neuroscience, 35(20):7813-7832  (2015).[pdf]

Siegel, J. J. & Mauk, M. D. Persistent activity in prefrontal cortex during trace eyelid conditioning: Dissociating responses that reflect cerebellar output from those that do not. Journal of Neuroscience, 33(38): 15272-15284, 2013. [pdf]

Li, W-K., Hausknecht, M. J. Stone. P. H. & Mauk, M. D. Using a million cell simulation of the cerebellum: Network scaling and task generality.  Neural Networks,47:95-102 (2013). [pdf]

Siegel, J. J., Kalmbach, B. E., Chitwood, R. A. & Mauk, M. D. Persistent activity in a cortical-to-subcortical circuit:  Bridging the temporal gap in trace eyelid conditioning. Journal of Neurophysiology, 107: 50-64, 2012. [pdf]

Kalmbach, B. E. & Mauk, M. D.  Multiple sites of extinction for a single learned response.  Journal of Neurophysiology, 107: 226-238, 2012. [pdf]

Kalmbach, B. E., Voicu, H., Ohyama, T. & Mauk, M. D. A subtraction mechanism of temporal coding in cerebellum.  Journal of Neuroscience, 31(6):2025–2034, 2011. [pdf]

Ohyama, T., Voicu, H., Kalmbach, B. E. & Mauk, M. D.  A decrementing form of plasticity apparent in cerebellar learning.  Journal of Neuroscience, 30(50):16993-17003, 2010. [pdf]

Kreider, J. C. & Mauk, M. D. Eyelid conditioning to a target amplitude. Journal of Neuroscience, 30(42):14145-14152, 2010. [pdf]

Kalmbach, B. E., Ohyama, T. & Mauk, M. D.  Temporal patterns of inputs to cerebellum necessary and sufficient for trace eyelid conditioning.  Journal of Neurophysiology,  104(2):627-640, 2010. [pdf]

Kalmbach, B. E., Davis, T., Ohyama, T., Nores, W. L. & Mauk, M. D.  Cerebellar cortex contributions to the expression and timing of conditioned eyelid responses.  Journal of Neurophysiology, 103: 2039-2049, 2010. [pdf]

Kalmbach, B. E., Ohyama, T., Kreider, J. C., Riusech, F. & Mauk, M. D. Cerebellum-forebrain interactions revealed by trace eyelid conditioning.  Learning & Memory, 16(1): 86-95, 2009. [pdf]

Hunt, P. S., Fanselow, M. S., Richardson, R., Mauk, M. D., Freeman, J. H. & Stanton, M. E.  Synapses, circuits, and the ontogeny of learning. Developmental Psychobiology, 49(7):649-663, 2007. [pdf]

Ohyama, T., Nores, W. L., Medina, J. F., Riusech, F. A. & Mauk, M. D. Learning-induced plasticity in cerebellar nucleus. Journal of Neuroscience, 26(49): 12656-12663, 2006. [pdf]

Voicu, H. & Mauk, M. D. Parametric analysis of cerebellar LTD in eyelid conditioning.  Neurocomputing 69: 1187-1190, 2006. [pdf]

Mauk, M. D. & Ohyama, T.  Extinction as new learning versus unlearning:  Considerations from a computer simulation of the cerebellum.  Learning & Memory, 11:566-571, 2004. [pdf]

Mauk, M. D & Buonomano, D. V.  Neural basis of temporal processing.  Annual Review of Neuroscience, 27:307-340, 2004. [pdf]

Ohyama, T., Nores, W. L. and Mauk, M. D. Stimulus generalization of conditioned eyelid responses produced without cerebellar cortex: Implications for plasticity in the cerebellar nuclei. Learning & Memory, 10, 346-354, 2003. [pdf]

Ohyama, T., Nores, W. L., Murphy, M. & Mauk, M. D.  What the cerebellum computes.  Trends in Neuroscience, 26(4), 222-227, 2003. [pdf]

Garcia, K. S., Mauk, M. D., Weidemann, G. and Kehoe, E. J.  Covariation of alternative measures of responding in rabbit eyeblink conditioning during acquisition training and tone generalization.  Behavioral Neuroscience, 117: 292-303, 2003. [pdf]

Ohyama, T., Medina, J. F., Nores, W. L. & Mauk, M. D. Trying to understand the cerebellum well enough to build one.  Annals  of the New York Academy of Sciences  978:1-15,  2002. [pdf]

Medina, J. F., Nores, W. L. and Mauk, M. D. Inhibition of climbing fibres is a signal for the extinction of conditioned eyelid responses.  Nature, 416, 330-333, 2002. [pdf]

Medina, J. F., Repa, J. C.,  Mauk, M. D. and LeDoux, J. E.  Parallels between cerebellar-dependent and amygdala-dependent conditioning.   Nature Reviews Neuroscience, 3(2): 122-131, 2002. [pdf]

Medina, J. F., Garcia, K. S. and Mauk, M. D. A mechanism for savings in the cerebellum. Journal of Neuroscience, 21:4081-4089, 2001. [pdf]

Ohyama, T. and Mauk, M. D.  Latent learning of timed responses in the cerebellar cortex  Journal of Neuroscience, 21:682-690, 2001. [pdf]

Medina, J. F., Nores, W. L., Ohyama, T. and Mauk, M. D. Mechanisms of cerebellar learning suggested by eyelid conditioning.  Current Opinion in Neurobiology, 10:717-724, 2000. [pdf]

Medina, J. F. and Mauk, M. D. Computer simulation of cerebellar information processing. Nature Neuroscience, 3:1205-1211, 2000. [pdf]

Mauk, M. D., Medina, J. F, Nores, W. L. and Ohyama, T.  Cerebellar function: Coordination, learning or timing? Current Biology, 10:R522-R525, 2000. [pdf]

Mauk, M. D. The potential effectiveness simulations versus phenomenological models.  Nature Neuroscience, 3:649-651, 2000. [pdf]

Medina, J. F., Garcia, K. S., Nores, W. L. Taylor, N. M. and Mauk, M. D. Timing mechanisms in the cerebellum: Testing predictions of a large scale computer simulation.  Journal of Neuroscience, 20: 5516-5525, 2000. [pdf]

Garcia, K. S., Steele, P. M. and Mauk, M. D. Cerebellar cortex lesions prevent acquisition of conditioned eyelid responses. Journal of Neuroscience, 19:10940-10947, 1999. [pdf]

Medina, J. F. and Mauk, M. D. Simulations of cerebellar motor learning: Computational analysis of plasticity at the mossy fiber to deep nucleus synapses. Journal of Neuroscience, 19:7140-7151, 1999. [pdf]

Steele, P. M. & Mauk, M. D. Inhibitory control of LTP and LTD: Stability of synapse strength. Journal of Neurophysiology, 81:1559-1566, 1999. [pdf]

Steele, P. M.,  Medina, J. F, Nores, W. L. and Mauk, M. D. Using genetic mutations to study the neural basis of behavior.  Cell, 95:879-882, 1998. [pdf]

Mauk, M. D. More than just another modifiable synapse. (preview) Neuron, 21:649-651, 1998. [pdf]

Garcia, K. S. and Mauk, M.D.  Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses.  Neuropharmacology, 37:471-480, 1998. [pdf]

Mauk, M.D., Garcia, K.S., Medina, J.F. and Steele, P.M. Does cerebellar LTD mediate motor learning?  Toward a resolution without a smoking gun.  Neuron, 20:359-362, 1998. [pdf]

Kenyon, G. T., Medina, J. F. & Mauk, M. D. A mathematical model of the cerebellar-olivary system II. Motor adaptation through systematic disruption of climbing fiber equilibrium. Journal of Computational Neuroscience, 5: 71-90, 1998. [pdf]

Kenyon, G. T., Medina, J. F. & Mauk, M. D. A mathematical model of the cerebellar-olivary system I: Self-regulating equilibrium of climbing fiber activity. Journal of Computational Neuroscience, 5: 17-33, 1998. [pdf]

Mauk, M. D. & Donegan, N. H. A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum. Learning & Memory, 4(1):130-158, 1997. [pdf]

Mauk, M. D. Steele, P. M. and Medina, J. F.  Cerebellar involvement in motor learning. The Neuroscientist, 3: 303-313, 1997. [pdf]

Mauk, M. D. Relative contributions of cerebellar cortex and nuclei in motor learning: Contradictions or clues?. Neuron, 18(3):343-349, 1997. [pdf]

Raymond, J., Lisberger, S.G. & Mauk, M. D. The cerebellum: A neuronal learning machine? Science, 272:1126-1132, 1996. [pdf]

Huber, K. M., Mauk, M. D. & Kelly, P. T. LTP induced by voltage-dependent Ca2+ channels requires protein kinase activity. Neuroreport, 6(9):1281-1284, 1995. [pdf]

Huber, K. M., Mauk, M. D., Thompson, C.  & Kelly, P. T. A critical period of protein kinase activity after tetenic stimulation is required for the induction of long-term potentiation. Learning & Memory, 2:81-100, 1995. [pdf]

Huber, K. M., Mauk, M. D. & Kelly, P. T.  Distinct mechanisms of LTP induction: Contribution of NMDA receptors and voltage-dependent calcium channels. Journal of Neurophysiology, 73:270-279, 1995. [pdf]

Perrett, S. P. & Mauk, M. D. Extinction of conditioned eyelid responses requires the anterior lobe of cerebellar cortex. Journal of Neuroscience, 15(3):2074-2080, 1995. [pdf]

Buonomano, D. V. & Mauk, M. D.  Neural network model of the cerebellum: Temporal discrimination and the timing of motor responses.  Neural Computation, 6(1): 38-55, 1994. [pdf]

Cormier, B., Mauk, M. D. & Kelly, P. T. Glutamate induces long-term potentiation in the absence of presynaptic transmitter release. Neuron, 10: 907-919, 1993. [pdf]

Waxham, M. N., Malenka, R. C., Kelly, P. T. & Mauk, M. D. Calcium/calmodulin-dependent protein kinase II regulates hippocampal synaptic transmission. Brain Research, 609:1-8, 1993. [pdf]

Perrett, S. P., Ruiz, B. P. & Mauk, M. D. Cerebellar cortex lesions disrupt the learning-dependent timing of conditioned eyelid responses. Journal of Neuroscience, 13(4):1708-1718, 1993. [pdf]

Mauk, M. D. & Ruiz, B. P. The learning-dependent timing of Pavlovian eyelid responses: Differential conditioning using multiple inter-stimulus intervals. Behavioral Neuroscience, 106: 666-681, 1992. [pdf]

Malenka, R. C., Kauer, J. A., Perkel, D. J., Mauk, M. D., Kelly, P. T., Nicoll, R. A. & Waxham, M. N.  Long-term potentiation: An essential role for postsynaptic calmodulin and protein kinase activity. Nature, 340:554-557, 1989. [pdf]

Skelton, R. W., Mauk, M. D., & Thompson, R. F.  Cerebellar nucleus lesions dissociate alpha conditioning from alpha responses in rabbits. Psychobiology, 16:126-134, 1988. [pdf]

Hiner, B., Mauk, M. D. Peroutka, S. J. & Kocsis, J. D.  Buspirone, 8-OH-DPAT and isapirone: non-serotonergic reductions in hippocampal, cerebellar and sciatic fiber excitability, Brain Research, 461:1-9,1988. [pdf]

Mauk, M. D., Peroutka, S. J. & Kocsis, J. D.  Buspirone attenuates synaptic activation of hippocampal pyramidal cells, Journal of Neuroscience, 8:1-11, 1988. [pdf]

Poolos, N. P., Mauk, M. D. & Kocsis, J. D.  Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus, Journal of Neurophysiology, 58:404-416, 1987. [pdf]

Mauk, M. D. & Thompson, R. F.  Retention of conditioned eyelid responses following acute decerebration, Brain Research, 403:89-95, 1987. [pdf]

Peroutka, S. J., Mauk, M. D. & Kocsis, J. D.  Modulation of hippocampal neuronal activity by 5-hydroxytryptamine and 5-hydroxytryptamine1A selective drugs, Neuropharmacology, 26:139-146, 1987. [pdf]

Peroutka, S. J., Heuring, R. E., Mauk, M. D. & Kocsis, J. D. Analysis of 5-HT1 binding sites and potential functional correlates, Psychopharmacology Bulletin, 22:813-817, 1986. [pdf]

Mauk, M. D., Steinmetz, J. E. & Thompson, R. F.  Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus, Proceedings of the National Academy of Science USA, 83:5349-5353, 1986. [pdf]

Lavond, D. G., Mauk, M. D., Madden, J. IV., Barchas, J. D. & Thompson, R. F.  Abolition of conditioned heart-rate responses in rabbits following central administration of [N-Me-Phe3-D-Pro4] morphiceptin, Pharmacology, Biochemistry & Behavior, 19:379-382, 1983. [pdf]

Mauk, M. D., Castellano, T. G., Rideout, J. A., Madden, J. IV., Barchas, J. D. & Thompson, R. F.  Overtraining reduces opiate abolition of classically conditioned responses, Physiology & Behavior, 30:494-495, 1983. [pdf]

Mauk, M. D., Madden, J. IV., Barchas, J. D. & Thompson, R. F.  Opiates and classical conditioning: Selective abolition of conditioned responses by activation of opiate receptors within the central nervous system, Proceedings of the National Academy of Science USA, 79:7598-7602, 1982. [pdf]

Mauk, M. D., Warren, J. T. & Thompson, R. F.  Selective, naloxone reversible morphine depression of learned behavioral and hippocampal responses. Science, 216:434-436, 1982. [pdf]

Mauk, M. D., Olson, R. D., LaHoste, G. J. & Olson, G. A.  Tonic immobility produces hyperalgesia and antagonizes morphine analgesia. Science, 213:353-354, 1981. [pdf]

Olson, G. A., Roig-Smith, R., Mauk, M. D., LaHoste, G. J., Coy, D. H., Hill, C. W. & Olson, R. D.  Differential effects of neuropeptides on short-term memory in primates, Peptides, 2:131-136, 1981.

Kastin, A. J., Mauk, M. D., Schally, A. V. & Coy, D. H.  An unusual dose-related effect of an endorphin analog in a complex maze. Physiology & Behavior, 25:959-962, 1980. [pdf]

Mauk, M. D., Olson, G. A., Kastin, A. J. & Olson, R. D.  Behavioral Effects of LH-RH, Neuroscience & Biobehavioral Reviews, 4:1-8, 1980. [pdf]

King, B. M., Castellanos, F. X., Kastin, A. J., Berzas, M.C., Mauk, M. D., Olson, G.A & Olson, R. D.  Naloxone-induced suppression of food intake in normal and hypothalamic-obese rats. Pharmacology, Biochemistry & Behavior, 11:729-732, 1979. [pdf]

Mauk, M. D. & Pavur, E. J. Jr.  Interconsequence generality of learned helplessness, Bulletin of the Psychonomic Society, 14(6): 421-423, 1979. [pdf]