The Raab-Graham lab has published a paper in the Journal of Biological Chemistry entitled “Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD”. Synopsis: The fate of a memory, whether stored or forgotten, is determined by the ability of […]
Drs. Mike Mauk and Alison Preston spearheaded a successful training grant submission for CLM. The grant is funded through NIMH and will provide 5 years of support for 2 graduate students and 4 years of support for 2 postdoctoral fellows that are training in CLM labs.
The Golding lab published a research article in Nature Neuroscience in collaboration with Dr. Philip Joris and colleagues from the University of Leuven. The paper, entitled “In vivo coincidence detection in mammalian sound localization generates phase delays”, reveals the mechanisms by which the brain computes spatial sound localization. Franken TP, Roberts MT, Wei L, Golding NL and Joris […]
Dr. Kristen Harris received a Scientific Innovations Award from the Brain Research Foundation for her reserach proposal entitled “Synaptome of Memory”. This project will focus on identifying the progression and ultrastructural consequences of activity-dependent synapse remodeling in a cellular mechanism of learning and memory.
The Colgin lab has published a paper in the journal Hippocampus entitled “The Relationship Between Gamma Frequency and Running Speed Differs for Slow and Fast Gamma Rhythms in Freely Behaving Rats”. This research investigates the way that different subtypes of gamma rhythms in the hippocampus correlate differently with rats’ behavior. Specifically, the frequency of fast gamma […]
Dr. Laura Colgin received a 5 year R01 grant from NIMH to study the roles of slow and fast gamma oscillations in memory processing. The proposed work will test the hypothesis that slow and fast gamma oscillations perform distinct functions in the hippocampal network, with fast gamma promoting memory encoding and slow gamma mediating memory retrieval.
The Raab-Graham lab recently published a research article in the journal Molecular Psychiatry entitled “Rapid Antidepressant Stimulates 14-3-3η Decoupling of GABABR from GIRK/Kir3″. For over 20 years it has been known that N-methyl-D-aspartate receptor (NMDAR) antagonists are effective as rapid antidepressants, however the underlying molecular mechanism of how NMDAR antagonists caused neuroadaptive changes in the brain […]
Congratulations to Dr. Rick Aldrich, who was elected as a Fellow of the American Association for the Advancement of Science (AAAS). The AAAS is an international non-profit organization dedicated to advancing science for the benefit of all people. Election as a Fellow of AAAS is an honor bestowed upon AAAS members by their peers. Fellows […]
Dr. Darrin Brager, in collaboration with Dr. Boris Zemelman, was awarded a new 5-year NIH R01 grant to study ion channels and dendrites in a mouse model of Fragile X syndrome.
Dr. Lewis-Peacock co-published a manuscript with Dr. Kenneth Norman (Princeton University) in Nature Communications entitled “Competition between items in working memory leads to forgetting”. Rapidly switching the focus of attention is believed to impair memory but it is unclear how. Lewis-Peacock and Norman use brain imaging and multivariate analysis to show that when two memories […]