Richard Gray, Ph.D.

 

 

Curriculum Vitae
Richard A. Gray, Ph.D.

Current Position and Address: Research Scientist
  Center for Learning and Memory
  College of Natural Sciences
  The University of Texas at Austin
  1 University Station Stop C7000
  Austin, TX 78712
   
  Email: rick@mail.clm.utexas.edu
   
Date and Place of Birth:
November 28, 1952; Savanna, Illinois
   
Marital Status: Single
   
Education: University of Illinois, Urbana-Champaign;
  B.S., Physiology & Biophysics, 1978
   
  Baylor College of Medicine, Houston, Texas;
  Ph.D., Neuroscience, 1988
   
Professional Background:  
1989-2004 Assistant Professor
  Division of Neuroscience and Department of Neurology
  Baylor College of Medicine, Houston
   
1989 Visiting Scientist
  Neurosciences Department
  Roche Institute of Molecular Biology
  Nutley, New Jersey
   
1988-1989 Instructor
  Department of Neurology
  Baylor College of Medicine, Houston
   
Professional Groups: Society for Neuroscience
   
Research Interests: Physiological and pathological modulation of the electrical properties of excitable cells.
   
Teaching Activities:  
2005-present Lecturer in Foundations of Cellular Neurophysiology (BIOL 337)
1990-1995 Guest lecturer in Molecular Neuroscience course
1983-2000 Computer Lab part of Cellular Neurophyisology Course
1978-Present Member, Neurophysiology Journal Club

Other scientific skills and interests:
  1. Electronic typesetting. I completely typeset the textbook by Johnston, D. and Wu, S. Foundations of Cellular Neurophysiology. MIT Press: Cambridge, 1995.
  2. Computer modeling of neurons. I created simulations to produce most of the figures in the textbook mentioned above, as well as developed the computer simulation section of a cellular neurophysiology course.
  3. Electronics for neurophysiology. I have designed, built, or modified several electronic devices used in cellular neurophysiology experiments.
  4. Laboratory computer integration. I have played a major role in the design and implementation of computer-based electrical and optical recording systems using a variety of computer types and operating systems.
  5. Web integration of neural simulations and database functions. I’ve written web-based frontends for neuron simulations, scientific-journal editorship functions, lab inventory, and departmental requisition systems using code written with HTML, PHP, and mySQL.
Bibliography:

Full Papers and Review Articles

  1. Merickel, M. B. and Gray, R. Investigations of burst generation by the electrically coupled cyberchron network in the snail Helisoma using a single electrode voltage clamp. J. Neurobiol. 11:73-102, 1980.
  2. Merickel, M. B., Gray, R., Chauvin, P. and Appel, S. Cultured muscle from myotonic muscular dystrophy patients: Altered membrane electrical properties. Proc. Natl. Acad. Sci. (USA) 78:648-652, 1981.
  3. Merickel, M. B. and Gray, R. Electrophysiology of human muscle in culture. Exp. Neurol. 72:281-293, 1981.
  4. Merickel, M. B., Gray, R., Chauvin, P. and Appel, S. Physiology of myotonic muscular dystrophy in culture. In: Diseases of the Motor Unit, Proceedings of the MDA Sixth International Conference. Schotland, D. (ed.) Houghton Mifflin, 1981.
  5. Appel, S.H., Merickel, M.B., Gray, R. and Moore, R.B. Membrane abnormalities in the myotonic disorders. In: Neuromuscular Diseases. Serratrice, G. (ed). Raven Press, New York. pp. 167-172.
  6. Johnston, D., Hopkins, W. F., and Gray, R. Cellular mechanisms of noradrenergic enhancement of long-term synaptic potentiation in hippocampus. In: The Role of Neuroplasticity in the Response to Drugs. Friedman, D. P. and Clouet, D. H. (eds.), NIDA Research Monograph Series, Vol. 78: Rockville, MD, 1987, pp. 95-107.
  7. Gray, R. A. and Johnston, D. Rectification of single GABA-gated chloride channels in adult hippocampal neurons. J. Neurophysiol. 54:134-142, 1985.
  8. Gray, R. and Johnston, D. Noradrenaline and beta-adrenoceptor agonists increase the activity of voltage-dependent calcium channels in hippocampal neurones. Nature 327:620-622, 1987.
  9. Johnston, D., Hopkins, W. F., and Gray, R. Noradrenergic enhancement of long-term synaptic potentiation. In: Long-Term Potentiation: From Biophysics to Behavior. Landfield, P. W. and Deadwyler, S. (eds.), Alan R. Liss: New York, 1988, pp. 355-376.
  10. Johnston, D., Hopkins, W.F., and Gray, R. Norepinephrine enhances long-term potentiation at hippocampal mossy fiber synapses. In: Synaptic Plasticity in the Hippocampus. Haas, H.L. and Buzsāki, G., (eds.), Springer-Verlag: Berlin, 1988, pp. 57-60.
  11. Johnston, D., Hopkins, W.F., and Gray, R. The role of norepinephrine in long-term potentiation at mossy fiber synapses in the hippocampus. In: Neural Models of Plasticity. Byrne, J.H. and Berry, W.O. (eds.), Academic Press, Inc.: San Diego, 1989, pp. 307-328.
  12. Gray, R. Patch clamp analysis of ligand and voltage gated ion channels in adult hippocampal neurons. Ph.D. Dissertation, Program in Neuroscience, Baylor College of Medicine, 1988.
  13. Johnston, D., Williams, S.H., Gray, R, and Fisher, R.E. Cholinergic and noradrenergic modulation of long-term potentiation in hippocampal CA3 neurons. In: Brain Signal Transduction and Memory. Ito, M. and Nishizuka, Y. (eds.), Academic Press, Inc.: San Diego, 1989, pp. 171-183.
  14. Gray, R., Fisher, R., Spruston, N., and Johnston, D. Acutely Exposed Hippocampal Neurons: A Preparation for Patch Clamping Neurons from Adult Hippocampal Slices. In: Preparations of Vertebrate Central Nervous Systems In vitro. H. Jahnsen, (ed.), John Wiley & Sons, Ltd.: Chichester, 1990, pp. 3-24.
  15. Fisher, R., Gray, R., and Johnston, D. Properties and distribution of single voltage-gated calcium channels in adult hippocampal neurons. J. Neurophysiol. 64:91-104, 1990.
  16. Chetkovich, D.M., Gray, R., Johnston, D., and Sweatt, J.D. NMDA-receptor activation increases cAMP levels and voltage-gated Ca2+-channel activity in area CA1 of hippocampus. Proc. Nat. Acad. Sci. (USA) 88:6467-6471, 1991.
  17. Johnston, D., Fisher, R.E., and Gray, R. Voltage-gated calcium channels in adult hippocampal neurons. In: Ion Channels, Volume III. Narahashi, T., (ed.), Plenum Publishing Corp: New York, 1992, pp. 39-62.
  18. Johnston, D., Williams, S., Jaffe, D., and Gray, R. NMDA-receptor independent long-term potentiation. Annu. Rev. of Physiol., 54:489-505, 1992.
  19. Gray, R., Rajan, A.S., Radcliffe, K.A., Yakehiro, M., and Dani, J.A. Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature, 383:713-716, 1996.
  20. Kapur, A., M. F. Yeckel, Gray, R., and Johnston, D. (1998). L-type calcium channels are required for one form of hippocampal mossy fiber LTP. J. Neurophysiol. 79(4): 2181-2190, 1998.
  21. Liang, Y., L. L. Yuan, Johnston, D., Gray, R. Calcium Signaling at Single Mossy Fiber Presynaptic Terminals in the Rat Hippocampus. J Neurophysiol. 87(2): 1132-1137, 2002.
  22. Johnston, D., Christie, B.R., Frick, A., Gray, R., Hoffman, D.A., Schexnayder, L.K., Watanabe, S., and Yuan, L.-L. Active dendrites, potassium channels, and synaptic plasticity. Philos. Trans. R. Soc. Lond. [Biol.] 358:667-674, 2003
  23. Johnston, D., Christie, B.R., Frick, A., Gray, R., Hoffman, D.A., Schexnayder, L.K., Watanabe, S., and Yuan, L.-L. Active dendrites, potassium channels, and synaptic plasticity. In: Long-term Potentiation: Enhancing Neuroscience for 30 years. Bliss, T.V.P., Collingridge, G.L., and Morris, R.G.M. (eds.), Oxford University Press: New York, 2004, pp. 95-107
  24. Liang, Y., Johnston, D., and Gray, R. Presynaptic Internal Calcium Release Enhances Transmission at Mossy fiber-CA3 Synapses. (in preparation), 2004.
Abstracts
  1. Merickel, M. B. and Gray, R. Identification of a non-decaying outward current in an electrically coupled bursting network in the snail. Soc. for Neurosci. Abs. 4:383, 1978.
  2. Merickel, M. B. and Gray, R. Membrane properties of rat skeletal muscle in primary tissue culture. Biophys. J. 25(2):200a, 1979.
  3. Merickel, M. B., Gray, R., Chauvin P. and Appel, S. Electrophysiology of myotonic muscular dystrophy in culture. Soc. for Neurosci. Abs. 5:378, 1979.
  4. Merickel, M. B. and Gray R. The role of Ca++ in the action potential of primary cultured rat myotubes. Fed. Proc. 39(6):2038, 1980.
  5. Merickel, M. B., Gray, R., Chauvin, P. and Appel S. Abnormal electrical properties of myotonic muscular dystrophy in culture observed with voltage clamp. Soc. for Neurosci. Abs. 6:303, 1980.
  6. Gray, R. and Merickel, M.B. Modulation of the action potential and ionic currents in primary cultured rat muscle. Soc. for Neurosci. Abs. 7:903, 1981.
  7. Merickel, M. B., Gray, R. and Moore, R.B. Production of depolarizing afterpotentials by high internal and external calcium concentrations. Soc. for Neurosci. Abs. 7:903, 1981.
  8. Gray, R., Kellaway, J., and Johnston, D. Electrical properties of acutely isolated hippocampal neurons. Physiologist 25:221, 1982.
  9. Gray, R., Kellaway, J., and Johnston, D. Recordings of single GABA-activated channels from acutely-isolated hippocampal neurons. Soc. Neurosci. Abstr. 9:1189, 1983.
  10. Griffith, W.H., Gray, R., and Johnston, D. Patch-clamp recordings from hippocampal pyramidal neurons in synaptically-intact slice fragments. Soc. Neurosci. Abstr. 9:1190, 1983.
  11. Gray, R. and Johnston, D. Macroscopic calcium currents in acutely-exposed neurons from adult hippocampal slices. Biophys. J. 47:66a, 1985.
  12. Gray, R. and Johnston, D. Macroscopic calcium currents in acutely-exposed granule cells from adult hippocampus. Soc. Neurosci. Abstr. 11:792, 1985.
  13. Gray, R. and Johnston, D. Multiple types of calcium channels in acutely-exposed neurons from adult hippocampus. Biophys. J. 49:432a, 1986.
  14. Gray, R. and Johnston, D. Multiple types of calcium channels in acutely exposed neurons from the adult guinea pig hippocampus. J. Gen. Physiol. 88:25a-26a, 1986.
  15. Johnston, D., Lebeda, F.J., Barber, S.O., Carnevale, N.T., and Gray, R. Functional reconstruction of hippocampal neurons. Fifth Annu. Conf. Biomed. Engrg., 1987.
  16. Johnston, D. and Gray, R. Norepinephrine through beta-adrenoceptors increases activity of single calcium channels in adult hippocampal granule cells. IBRO, 1987.
  17. Gray, R. and Johnston, D. Recordings of single calcium channels from presynaptic mossy fiber terminals in adult guinea pig hippocampus. Soc. Neurosci. Abstr. 14:68, 1988.
  18. Fisher, R.E., Gray, R., and Johnston, D. beta-adrenoceptor modulation of calcium channels in acutely exposed CA3 pyramidal neurons of adult guinea pig hippocampus. Soc. Neurosci. Abstr. 14:645, 1988.
  19. Chetkovich, D.M., Gray, R., Johnston, D., and Sweatt, J.D. NMDA receptors cause Ca2+-dependent increases in cAMP levels and Ca2+-channel activity. Soc. Neurosci. Abstr. 17:384, 1991.
  20. Jaffe, D.B., Williams, S.H., Gray, R., Spruston, N., and Johnston, D. Induction mechanisms for NMDA-receptor independent LTP in hippocampus. J. Cell. Biochem. 16E:222, 1992.
  21. Gray, R. Macroscopic currents from hippocampal mossy fiber presynaptic terminals. Soc. Neurosci. Abstr. 19:1519, 1993.
  22. Gray, R. and Dani, J.A. Presynaptic nicotinic receptors enhance glutamate release in the hippocampal slice and raise Ca2+ in single mossy-fiber terminals. Soc. Neurosci. Abstr. 22:1523, 1996.
  23. Hoffman, D., Magee, J., Gray, R., and Johnston, D. Modulation of transient, A-type K+ channels in dendrites of hippocampal CA1 pyramidal neurons. Soc. Neurosci. Abstr. 23:1394, 1997.
  24. Yuan, L.L, Johnston, D., and Gray, R. Characterization of presynaptic Ca2+ signaling at single mossy fiber terminals (MFTs). Soc. Neurosci. Abstr. 25:1253, 1999.
  25. Liang, Y., L. L. Yuan, Johnston, D., Cook, E.P., Gray, R. Calcium signaling at single mossy fiber presynaptic terminals. Soc. Neurosci. Abstr. 26(1): 88, 2000.
  26. Yeckel, M. F., Y. Liang, Gray, R., Johnston, D. Kainate receptor-mediated release of Ca2+ from internal stores at hippocampal mossy fiber-CA3 synapses. Soc. Neurosci. Abstr. 26(2): 1389, 2000.
  27. Liang, Y., Johnston, D., and Gray, R. Presynaptic calcium release enhances transmssion at mossy fiber-CA3 synapses. Soc. Neurosci. Abstr. 686.4, 2003.

 

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