Kristen Harris and colleagues published an opinion article in a special issue of the Philosophical Transactions of the Royal Society B devoted to covering 50 years of progress on the study of plasticity in the brian. The article entitled "Synapse-specific structural plasticity that protects and refines local circuits during LTP and LTD" proposes a model for maintianing the strength and structure of synapses over time based on data from three- dimensional reconstruction from serial section electron microscopy of plasticity in pre and post-synaptic active zones.
Harris KM, Kuwajima M, Flores JC, Zito K. Synapse-specific structural plasticity that protects and refines local circuits during LTP and LTD. Philos Trans R Soc Lond B Biol Sci. 2024 Jul 29;379(1906):20230224. doi: 10.1098/rstb.2023.0224.